skip to main
For US Healthcare Professionals Only
Image of a blueprint of the Mona Lisa with text overlay 'Look below the surface into the MDM2-p53 interaction'.

Look below the surface 
into the MDM2-p53 
interaction

MDM2=mouse double minute 2.

What lies beneath the MDM2-p53 interaction

In DDLPS, excess MDM2 disrupts the guardian of the genome1-4

Diagram showing excess MDM2 disrupting p53, the guardian of the genome, leading to uncontrolled cell proliferation in Dedifferentiated liposarcoma (DDLPS Cancer).
Diagram showing excess MDM2 disrupting p53, the guardian of the genome, leading to uncontrolled cell proliferation in Dedifferentiated liposarcoma (DDLPS Cancer).
Diagram showing excess MDM2 disrupting p53, the guardian of the genome, leading to uncontrolled cell proliferation in Dedifferentiated liposarcoma (DDLPS Cancer).

  • p53 is a tumor suppressor and functions as the guardian of the genome by responding to oncogenic stress and inducing cell cycle arrest and apoptosis2

  • p53 is mutated in over 50% of cancers where its tumor suppressor function is compromised4

  • In tumors where p53 is not mutated, its function can be attenuated by other mechanisms. For example, the function of p53 is disrupted by the presence of excess MDM2 either by its amplification or overexpression5

  • MDM2 is a negative regulator of p53, and in DDLPS where it is present in excess, MDM2 binds to p53 and targets it for degradation3,4

DDLPS=dedifferentiated liposarcoma.

References:

  1. Sciot R. Diagnostics. 2021;11(3):496. doi:10.3390/diagnostics11030496

  2. Kung CP, Weber JD. Front Cell Dev Biol. 2022;10:818744. doi:10.3389/fcell.2022.818744

  3. Shaikh MF, Morano WF, Lee J, et al. Ann Clin Lab Sci. 2016;46(6):627-634.

  4. Nag S, Zhang X, Srivenugopal KS, Wang MH, Wang W, Zhang R. Curr Med Chem. 2014;21(5):553-574.

  5. Senturk E, Manfredi JJ. Genes Cancer. 2012;3(3-4):192-198.